Incorporating renal excretion via the OCT2 transporter in physiologically based kinetic modelling to predict in vivo kinetics of mepiquat in rat

This study demonstrates a proof-of-principle on how to include active renal excretion into generic PBK models.PMID:33639197 | DOI:10.1016/j.toxlet.2021.02.013

Source: Toxicology Letters - February 27, 2021 Category: Toxicology Authors: Annelies Noorlander Sebastiaan Wesseling Ivonne M C M Rietjens Bennard van Ravenzwaay Source Type: research