Shifts in the neurobiological mechanisms motivating cocaine use with the development of an addiction-like phenotype in male rats

ConclusionThese findings indicate that in contrast to NAc-D1R, D2R remain critical for motivating cocaine use with the development of an addiction-like phenotype. These findings also indicate that shifts in the mechanisms motivating cocaine use impact the response to both site-specific and systemic pharmacological treatment.

Source: Psychopharmacology - February 27, 2021 Category: Psychiatry Source Type: research