Cancers, Vol. 13, Pages 972: Anti-Tumor Effects of a Penetratin Peptide Targeting Transcription of E2F-1, 2 and 3a Is Enhanced When Used in Combination with Pemetrexed or Cisplatin

Conclusions: The D-Arg PEP in combination with cisplatin caused synergistic cell kill against prostate, breast, lung cancers, and the CCRF-CEM cell line. Marked synergy resulted when the D-Arg PEP was used in combination with pemetrexed against the lung adenocarcinoma cell lines. A xenograft study using the PL-PEP in combination with pemetrexed showed enhanced anti-tumor effects compared to each drug alone.

Source: Cancers - February 26, 2021 Category: Cancer & Oncology Authors: Gulam Mohmad Rather Michael Anyanwu Tamara Minko Olga Garbuzenko Zoltan Szekely Joseph R. Bertino Tags: Article Source Type: research