Early occupational exposure to lead on neutrophil-to-lymphocyte ratio and genotoxicity

CONCLUSION: Our large-scale population study shows that Pb exposure increased NLR and induced genotoxicity. There was an association between elevated NLR and DNA damage. In addition, the mediation effect of % tail DNA on the relationship between BLLs and NLR provided mechanistic evidence that certain mechanisms, e.g. inflammation, may be involved in elevation of NLR from Pb exposure. Therefore, NLR may be a convenient and sensitive biomarker for indication of Pb toxicity. Further studies are needed to validate the proposed mechanism and NLR as a biomarker.PMID:33618327 | DOI:10.1016/j.envint.2021.106448

Source: Environment International - February 22, 2021 Category: Environmental Health Authors: Yu Meng Kan Wang Tuanwei Wang Yuting Tu Shiyang Gong Yunxia Zhang Guanghui Zhang William Au David C Christiani Zhao-Lin Xia Source Type: research