Positive and negative effects of perampanel treatment on psychiatric and behavioral symptoms in adult patients with epilepsy

CONCLUSIONS: Perampanel therapy may aggravate or even ameliorate psychiatric and behavioral symptoms in patients with epilepsy. The psychiatric and behavioral prognoses after administration of PER vary depending on the type of psychiatric and behavioral comorbidities in patients with epilepsy. Psychiatric and behavioral symptoms may improve in patients with successful suppression of seizures by PER. Additionally, combination therapy consisting of PER and carbamazepine may be associated with good outcomes of psychiatric and behavioral symptoms in patients with epilepsy.PMID:33610462 | DOI:10.1016/j.yebeh.2020.107515
Source: Epilepsy and Behaviour - Category: Neurology Authors: Source Type: research