The effect of variable troponin C mutation thin filament incorporation on cardiac muscle twitch contractions

One of the complexities of understanding the pathology of familial forms of cardiac diseases is the level of mutation incorporation in sarcomeres. Computational models of the sarcomere that are spatially explicit offer an approach to study aspects of mutational incorporation into myofilaments that are more challenging to get experimentally. We studied two well characterized mutations of cardiac TnC, L48Q and I61Q, that decrease or increase the release rate of Ca2+ from cTnC, k −Ca, resulting in HCM and DCM respectively [1].

Source: Journal of Molecular and Cellular Cardiology - February 23, 2021 Category: Cytology Authors: Srboljub M. Mijailovich, Momcilo Prodanovic, Corrado Poggesi, Joseph D. Powers, Jennifer Davis, Michael A. Geeves, Michael Regnier Source Type: research