Reply to: “Obeticholic acid and hepatic bile acids: Excellent study faulty conclusion”

We appreciate the interest of Norman B Javitt1 in our recent study in patients with primary biliary cholangitis concerning the effect of obeticholic acid on the transport of the bile acid tracer [N-methyl-11C]cholylsarcosine (11C-CSar) from blood to bile, using positron emission tomography (PET).2 Dr. Javitt questions the conclusion of our study that obeticholic acid enhances the secretion of endogenous conjugated bile acids in the patients. However, Dr. Jawitt seems not to be familiar with the possibilities for quantification of biological processes in vivo by up-to-date molecular tracer technique using dynamic PET.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research