Calcific aortic valve disease: turning therapeutic discovery up a notch

Nature Reviews Cardiology, Published online: 19 February 2021; doi:10.1038/s41569-021-00528-1Valve replacement is currently the only treatment for calcific aortic valve disease. Studies of an uncommon, genetic form of aortic valve disease have yielded in vitro and mouse models of the disease and a transcriptomic disease signature. Machine learning-driven screens for compounds that normalize this signature promise to enable medical management of aortic valve disease.
Source: Nature Reviews Cardiology - Category: Cardiology Authors: Source Type: research