Interleukin ‐7/Interferon Axis Drives T Cell and Salivary Gland Epithelial Cell Interactions in Sjögren’s Syndrome

ConclusionThese results suggest the presence of an IL ‐7/IFNγ amplification loop involving SGECs and T cells in primary SS. IL‐7 was secreted by SGECs stimulated with type I or type II IFN and, in turn, activated T cells that secrete type II IFN. An anti–IL‐7R antibody decreased the IFN signature in T cells in primary SS and could be of therap eutic interest.

Source: Arthritis and Rheumatology - February 16, 2021 Category: Rheumatology Authors: Elodie Rivi ère, Juliette Pascaud, Alexandre Virone, Anastasia Dupré, Bineta Ly, Audrey Paoletti, Raphaèle Seror, Nicolas Tchitchek, Michael Mingueneau, Nikaïa Smith, Darragh Duffy, Lydie Cassard, Nathalie Chaput, Sabrina Pengam, Vanessa Tags: Full Length Source Type: research