Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma

Activating G αq signalling mutations are considered an early event in the development of uveal melanoma. Whereas most tumours harbour a mutation in GNAQ or GNA11, CYSLTR2 (encoding G-protein coupled receptor CysLT

Source: BMC Cancer - February 15, 2021 Category: Cancer & Oncology Authors: Rogier J. Nell, Nino V. Menger, Mieke Versluis, Gregorius P. M. Luyten, Robert M. Verdijk, Michele C. Madigan, Martine J. Jager and Pieter A. van der Velden Tags: Research article Source Type: research