Immune Cell Membrane ‐Coated Biomimetic Nanoparticles for Targeted Cancer Therapy

Biocompatibility and targeting potential are the main features of immune cell membranes, which have rendered them the potential of being used as coating platforms for biomimetic nanoparticles for drug delivery, cancer therapy, and bioimaging. Herein, an overview of requirements for the successful coating of nanomedicines with cell membranes and the most recent progresses in their biomedical applications are discussed. AbstractNanotechnology has provided great opportunities for managing neoplastic conditions at various levels, from preventive and diagnostic to therapeutic fields. However, when it comes to clinical application, nanoparticles (NPs) have some limitations in terms of biological stability, poor targeting, and rapid clearance from the body. Therefore, biomimetic approaches, utilizing immune cell membranes, are proposed to solve these issues. For example, macrophage or neutrophil cell membrane coated NPs are developed with the ability to interact with tumor tissue to suppress cancer progression and metastasis. The functionality of these particles largely depends on the surface proteins of the immune cells and their preserved function during membrane extraction and coating process on the NPs. Proteins on the outer surface of immune cells can render a wide range of activities to the NPs, including prolonged blood circulation, remarkable competency in recognizing antigens for enhanced targeting, better cellular interactions, gradual drug release, and reduced toxicity in...
Source: Small - Category: Nanotechnology Authors: Tags: Review Source Type: research