At the heart of mitochondrial quality control: many roads to the top.

At the heart of mitochondrial quality control: many roads to the top.
Cell Mol Life Sci. 2021 Feb 05;:
Authors: Gottlieb RA, Piplani H, Sin J, Sawaged S, Hamid SM, Taylor DJ, de Freitas Germano J
Abstract
Mitochondrial quality control depends upon selective elimination of damaged mitochondria, replacement by mitochondrial biogenesis, redistribution of mitochondrial components across the network by fusion, and segregation of damaged mitochondria by fission prior to mitophagy. In this review, we focus on mitochondrial dynamics (fusion/fission), mitophagy, and other mechanisms supporting mitochondrial quality control including maintenance of mtDNA and the mitochondrial unfolded protein response, particularly in the context of the heart.
PMID: 33544154 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - February 5, 2021 Category: Cytology Authors: Gottlieb RA, Piplani H, Sin J, Sawaged S, Hamid SM, Taylor DJ, de Freitas Germano J Tags: Cell Mol Life Sci Source Type: research