Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer.

In this study, we identified MCL-1 as a critical molecule for chemo-resistance in A549 cells associated with TGF-β-induced EMT. Importantly, downregulation of MCL-1 by siRNA or inhibition of MCL-1 with pan-BCL2 inhibitor to inhibit MCL-1 was able to overcome the EMT-associated chemo-resistance in A549 cells. Collectively, MCL-1 can be a new therapeutic target for overcoming EMT-associated chemo-resistance in NSCLC patients in the context of post-operative chemotherapies.
PMID: 25647738 [PubMed - as supplied by publisher]

Source: International Journal of Oncology - January 30, 2015 Category: Cancer & Oncology Authors: Toge M, Yokoyama S, Kato S, Sakurai H, Senda K, Doki Y, Hayakawa Y, Yoshimura N, Saiki I Tags: Int J Oncol Source Type: research