Distress severity in perceptual anomalies moderates the relationship between prefrontal brain structure and psychosis proneness in nonclinical individuals.

In this study, brain structural variation was related to PLE level, but not distress severity, suggesting specificity. In healthy individuals, positive relationships between PLE and prefrontal volumes may indicate protective features, which supports the insufficiency of PLE for the prediction of CHR. Additional indicators of vulnerability, such as distress associated with perceptual PLE, change the positive brain structure relationship. Brain structural findings may strengthen clinical objectives through disentanglement of innocuous and risk-related PLE. PMID: 33532868 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33532868?dopt=Abstract

Source: European Archives of Psychiatry and Clinical Neuroscience - February 5, 2021 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research