Endothelial NADPH oxidase 4 protects against angiotensin II ‐induced cardiac fibrosis and inflammation

ConclusionsA chronic increase in endothelial Nox4 stimulates physiological cardiac hypertrophy and protects against AngII ‐induced cardiac fibrosis by inhibiting EC activation and the recruitment of inflammatory cells.Highlights

Mice with endothelium ‐specific overexpression of Nox4 (EndoNox4 TG) exhibit eccentric hypertrophy with well‐preserved cardiac function at baseline.
EndoNox4 TG mice develop significantly less interstitial cardiac fibrosis in response to chronic pressure AngII stimulation, independent of cardiac hypertrophy.
Overexpr ession of Nox4 in endothelial cells reduces AngII‐induced endothelial activation.
An increase in endothelial Nox4 inhibits AngII‐induced recruitment of inflammatory cells in the heart.

Source: ESC Heart Failure - January 29, 2021 Category: Cardiology Authors: Minshu Wang, Colin E. Murdoch, Alison C. Brewer, Aleksandar Ivetic, Paul Evans, Ajay M. Shah, Min Zhang Tags: Original Research Article Source Type: research