Is Regression of Left Ventricular Hypertrophy Really a Good Thing for Patients with Hypertrophic Cardiomyopathy?: The Emerging Mavacamten Story

The 60-year history of hypertrophic cardiomyopathy has been periodically encumbered by uncertainties regarding its very nature and pathophysiology, including popular myths about the disease, some of which have persisted to this day.1 One such example is the belief that the clinical course of hypertrophic cardiomyopathy can be reversed by eliminating or substantially reducing left ventricular (LV) hypertrophy itself, the sine qua non and primary diagnostic and pathophysiologic feature of this complex inherited disease.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research