Synthesis of d-glycopyranosyl depsipeptides using Passerini reaction.

Synthesis of d-glycopyranosyl depsipeptides using Passerini reaction.
Carbohydr Res. 2021 Jan 11;500:108236
Authors: Kumar B, Maity J, Shankar B, Kumar S, Kavita, Prasad AK
Abstract
A protocol based on Passerini multi-component reaction has been developed for facile, efficient and atom economical synthesis of a small library of twenty potential bioactive (2R)-2-(d-glycopyranosyl)-2-acyloxyacetamides using perbenzylated d-glycopyranosyl aldehydes, substituted isocyanides and different aliphatic/aromatic carboxylic acids. All twenty synthesized d-glycopyranosyl α-acyloxy amides, commonly known as depsipeptides were unambiguously identified on the basis of their spectral (IR, 1H, 13C NMR, COSY, HSQC, NOESY and HRMS) data analysis.
PMID: 33516073 [PubMed - as supplied by publisher]

Source: Carbohydrate Research - January 11, 2021 Category: Genetics & Stem Cells Authors: Kumar B, Maity J, Shankar B, Kumar S, Kavita, Prasad AK Tags: Carbohydr Res Source Type: research