Development of an Antigen-Specific T Cell Assay to Identify Food Triggers in Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is a chronic, T cell mediated disease that is triggered by specific foods and results in odynophagia and progressive esophageal dysfunction. Due to the absence of food-specific IgE antibodies in some EoE patients, skin prick testing is not reliably helpful when attempting to identify EoE-causal foods. As such, the current standard of care involves empiric food elimination diets or swallowed steroids with repeated endoscopies. There is significant need for a quick, non-invasive laboratory test which can accurately predict tolerated and trigger foods in EoE patients.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Julianna Dilollo, Elizabeth Martin, David Hill, Jonathan Spergel Source Type: research
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