Higher Intensity Therapy and Surgical Risk in Esophageal Cancer Higher Intensity Therapy and Surgical Risk in Esophageal Cancer

Combining standard neoadjuvant chemotherapy for locally advanced esophageal cancer with either radiation or docetaxel did not increase the risk of surgical complications, investigators in the JCOG1109 trial reported.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

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We examined the association of volume, program accreditation, safety net status, geographic region, patient travel distance on adequate adherence (≥85% of patients are adherent) using logistic regression modeling.RESULTS: The rate of adequate adherence was worst in nodal staging (12.6%) and highest for utilization of neoadjuvant therapy (84.8%). Academic programs had the highest rate of adequate adherence for induction therapy (77.2%, p
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
We read with interest the systematic review and meta-analysis by Li et al1 comparing lower and higher radiation doses for operable esophageal/gastroesophageal junction carcinoma. This is a topical article, with several other recent systematic reviews and meta-analyses reporting on high-dose relative to low-dose chemoradiation therapy.2,3 In contrast to some other meta-analyses, the article by Li et al reports that neoadjuvant chemotherapy with low-dose radiation therapy may offer superior overall survival, progression-free survival, toxicity, and distant failure rates compared with high-dose radiation therapy.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Radiation Dose for Operable Esophageal/GEJ Cancer Source Type: research
Summary: Postoperative tracheoesophageal or bronchoesophageal fistulas represent a major surgical challenge. The authors report the description of an original perforator-based intercostal artery muscle flap, aiming to cover all types of intrathoracic fistulas, from any location, in difficult cases such as postoperative fistulas after esophagectomy in an irradiated field. Between June of 2016 and January of 2019, eight male patients were treated with a perforator-based intercostal artery muscle flap. All had previous surgery for esophageal cancer and developed a tracheoesophageal or bronchoesophageal fistula during the ...
Source: Plastic and Reconstructive Surgery - Category: Cosmetic Surgery Tags: Reconstructive: Head and Neck: Ideas and Innovations Source Type: research
Ann Surg Oncol. 2021 Apr 21. doi: 10.1245/s10434-021-09999-5. Online ahead of print.ABSTRACTBACKGROUND: Neoadjuvant chemotherapy with concurrent radiotherapy (nCRT) is an accepted treatment regimen for patients with potentially curable esophageal and gastroesophageal junction (GEJ) adenocarcinoma. The purpose of this study is to evaluate whether induction chemotherapy (IC) before nCRT is associated with improved pathologic complete response (pCR) and overall survival (OS) when compared with patients who received nCRT alone for esophageal and GEJ adenocarcinoma.METHODS: Using the National Cancer Database (NCDB), patients wh...
Source: Ann Oncol - Category: Cancer & Oncology Authors: Source Type: research
Conditions:   Esophageal Cancer;   Chemotherapy Effect;   Chemoradiation;   Surgery;   Targeted Therapy;   Immunotherapy;   Esophagogastric Juction Cancer Interventions:   Drug: Platinum based chemotherapy;   Drug: Paclitaxel based chemotherapy;   Radiation: Radiotherpay;   Procedure: Surgery;   Drug: Immunotherapy;   Drug: 5-FU Analog based chemotherpay;   Drug: Nimotuzumab Sponsor:   Chinese Academy of Medical Sciences Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
. Field This scoping review examines the evidence for n-3 long-chain polyunsaturated fatty acid [LCPUFA, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] supplementation in clinical cancer therapy. A comprehensive literature search was performed to identify relevant clinical intervention studies conducted through August 2020. Fifty-seven unique cancer trials, assessing EPA and/or DHA supplementation pre- or post-treatment, concomitant with neoadjuvant chemotherapy, radiation or surgery, or in palliative therapy were included. Breast, head and neck, gastrointestinal, gastric, colorectal/rectal, esophageal, le...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Tajima Ozawa In Japan, the therapeutic strategies adopted for esophageal carcinoma are based on the results of multi-institutional trials conducted by the Japan Esophageal Oncology Group (JEOG), a subgroup of the Japan Clinical Oncology Group (JCOG). Owing to the differences in the proportion of patients with squamous cell carcinoma among all patients with esophageal carcinoma, chemotherapeutic drugs available, and surgical procedures employed, the therapeutic strategies adopted in Asian countries, especially Japan, are often different from those in Western countries. The emphasis in respect of postoperative adjuva...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
CONCLUSIONS: Post-esophagectomy paraconduit hernia is more common following totally minimally invasive esophagectomy compared with open or hybrid techniques. One-third are symptomatic and the remainder detected only radiographically. Repair of asymptomatic hernias should take into consideration the patient's cancer prognosis. PMID: 33031780 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
Conclusions: This single-institution study demonstrated the feasibility of SBRT for locoregional recurrence of esophageal cancer with minimal treatment-related toxicity and high rates of treated tumor control. Prospective studies identifying ideal salvage SBRT candidates for locoregional failure as well as validating its safety are needed.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Condition:   Esophageal Neoplasm Interventions:   Radiation: Neo-Adjuvant Radiotherapy;   Drug: Neo-Adjuvant Chemotherapy;   Procedure: Esophagectomy Sponsor:   Dr Kundan Singh Chufal Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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