Clade GR and clade GH isolates of SARS-CoV-2 in Asia show highest amount of SNPs.

In this study, 1566 SARS-CoV-2 genome sequences across ten Asian countries are collected, clustered, and characterized based on the clade they belong to. The isolates are compared to the Wuhan reference sequence" hCoV-19/Wuhan/WIV04/19″ to identify the mutations that occurred at different protein regions. Structural changes in amino acids due to mutations lead to functional instability of the proteins. Detailed clade-wise functional assessments are carried out to quantify the stability and vulnerability of the mutations occurring in SARS-CoV-2 genomes which can shade light on personalized prevention and treatment of the disease and encourage towards the invention of clade-specific vaccines. PMID: 33476804 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33476804?dopt=Abstract

Source: Infection, Genetics and Evolution - January 18, 2021 Category: Genetics & Stem Cells Authors: Sengupta A, Hassan SS, Choudhury PP Tags: Infect Genet Evol Source Type: research