P-glycoprotein inhibition with verapamil overcomes mometasone resistance in Chronic Sinusitis with Nasal Polyps.

CONCLUSIONS: Our study confirms that P-gp contributes to mometasone resistance. This P-gp mediated resistance was successfully reversed by addition of the P-gp inhibitor verapamil. Verapamil further significantly enhanced the anti-inflammatory effect of mometasone when given as a combination therapy. PMID: 33459729 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33459729?dopt=Abstract

Source: Rhinology - January 21, 2021 Category: ENT & OMF Tags: Rhinology Source Type: research