Association between antiviral treatment and extrahepatic outcomes in patients with hepatitis C virus infection

Chronic infection with the hepatitis C virus (HCV) is a slow progressive disease. While fibrosis development may not be linear over time, it has been estimated that 15–20% of patients will establish cirrhosis within 20 years of HCV acquisition.1 Once cirrhosis is present, it is clear that the patient's prognosis is heavily affected, with a 3–5% annual risk of liver failure as well as hepatocellular carcinoma (HCC). Although liver transplantation may be lifesaving in selected cases, organ shortage remains an important limitation. As a result, cirrhosis-related complications are considered to be one of the main reasons why chronic HCV infection is associated with an impaired overall survival.2 Fortunately, many HCV-infected patients are not expected to develop advanced hepatic fibrosis. Are these patients unaffected by the virus? Probably not. Chronic HCV infection remains a multifaceted disease, which is not restricted to the liver. Patients may experience a...
Source: Gut - Category: Gastroenterology Authors: Tags: Commentary Source Type: research