Distinct airway involvement in subtypes of end-stage fibrotic pulmonary sarcoidosis.

Distinct airway involvement in subtypes of end-stage fibrotic pulmonary sarcoidosis.
Chest. 2021 Jan 10;:
Authors: Verleden SE, Vanstapel A, De Sadeleer L, Dubbeldam A, Goos T, Gyselinck I, Geudens V, Kaes J, Van Raemdonck DE, Ceulemans LJ, Yserbyt J, Vos R, Vanaudenaerde B, Weynand B, Verschakelen J, Wuyts WA
Abstract
BACKGROUND: Sarcoidosis is a systemic granulomatous disease that in most cases affects the lung. Pulmonary fibrotic sarcoidosis is clinically, radiologically and pathologically a heterogeneous condition. Although there is substantial indirect evidence of small airway involvement, direct evidence is currently lacking.
RESEARCH QUESTION: to investigate the role of the (small) airways in fibrotic sarcoidosis.
STUDY DESIGN: and methods: Airway morphology was investigated in 7 explant lungs with end-stage fibrotic sarcoidosis using a combination of CT (large airways), microCT (small airways) and histology and compared to 7 unused donor lungs as controls with specific attention for different radiologically defined sarcoidosis subtypes.
RESULTS: Patients with central bronchial distortion (n=3), diffuse bronchiectasis (n=3) and UIP pattern (n=1) were identified based on CT scan, showing respectively a decrease and narrowing of large airways, a similar airway number and increased airway diameter of more distal airways or an increase in airway number and airway diameter compared to controls. The number of...

Source: Chest - January 10, 2021 Category: Respiratory Medicine Authors: Verleden SE, Vanstapel A, De Sadeleer L, Dubbeldam A, Goos T, Gyselinck I, Geudens V, Kaes J, Van Raemdonck DE, Ceulemans LJ, Yserbyt J, Vos R, Vanaudenaerde B, Weynand B, Verschakelen J, Wuyts WA Tags: Chest Source Type: research