Viruses, Vol. 13, Pages 93: Identification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain
Viruses, Vol. 13, Pages 93: Identification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain
Viruses doi: 10.3390/v13010093
Authors:
Javier E. Cañada
Elena Delgado
Horacio Gil
Mónica Sánchez
Sonia Benito
Elena García-Bodas
Carmen Gómez-González
Andrés Canut-Blasco
Joseba Portu-Zapirain
Ester Sáez de Adana
Mireia De la Peña
Sofía Ibarra
Gustavo Cilla
José Antonio Iribarren
Ana Martínez-Sapiña
Michael M. Thomson
The extraordinary genetic variability of human immunodeficiency virus type 1 (HIV-1) group M has led to the identification of 10 subtypes, 102 circulating recombinant forms (CRFs) and numerous unique recombinant forms. Among CRFs, 11 derived from subtypes B and C have been identified in China, Brazil, and Italy. Here we identify a new HIV-1 CRF_BC in Northern Spain. Originally, a phylogenetic cluster of 15 viruses of subtype C in protease-reverse transcriptase was identified in an HIV-1 molecular surveillance study in Spain, most of them from individuals from the Basque Country and heterosexually transmitted. Analyses of near full-length genome sequences from six viruses from three cities revealed that they were BC recombinant with coincident mosaic structures different from known CRFs. This allowed the definition of a new HIV-1 CRF designated CRF108_BC, whose genome is predominantly of subtype C, with four short subtype B fragments. Phylogenetic analyses with database sequences supported ...
Source: Viruses - Category: Virology Authors: Javier E. Ca ñada Elena Delgado Horacio Gil M ónica Sánchez Sonia Benito Elena Garc ía-Bodas Carmen G ómez-González Andr és Canut-Blasco Joseba Portu-Zapirain Ester S áez de Adana Mireia De la Pe ña Sof ía Ibarra Gustavo Cilla Jos é Antonio Iri Tags: Article Source Type: research
More News: Brazil Health | China Health | Databases & Libraries | Genetics | Italy Health | Spain Health | Study | Virology