Viruses, Vol. 13, Pages 93: Identification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain

Viruses, Vol. 13, Pages 93: Identification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain Viruses doi: 10.3390/v13010093 Authors: Javier E. Cañada Elena Delgado Horacio Gil Mónica Sánchez Sonia Benito Elena García-Bodas Carmen Gómez-González Andrés Canut-Blasco Joseba Portu-Zapirain Ester Sáez de Adana Mireia De la Peña Sofía Ibarra Gustavo Cilla José Antonio Iribarren Ana Martínez-Sapiña Michael M. Thomson The extraordinary genetic variability of human immunodeficiency virus type 1 (HIV-1) group M has led to the identification of 10 subtypes, 102 circulating recombinant forms (CRFs) and numerous unique recombinant forms. Among CRFs, 11 derived from subtypes B and C have been identified in China, Brazil, and Italy. Here we identify a new HIV-1 CRF_BC in Northern Spain. Originally, a phylogenetic cluster of 15 viruses of subtype C in protease-reverse transcriptase was identified in an HIV-1 molecular surveillance study in Spain, most of them from individuals from the Basque Country and heterosexually transmitted. Analyses of near full-length genome sequences from six viruses from three cities revealed that they were BC recombinant with coincident mosaic structures different from known CRFs. This allowed the definition of a new HIV-1 CRF designated CRF108_BC, whose genome is predominantly of subtype C, with four short subtype B fragments. Phylogenetic analyses with database sequences supported ...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research