Cross-reactive peptide epitopes of Enterovirus Coxsackie B4 and human Glutamic Acid Decarboxylase detecting antibodies in Latent Autoimmune Diabetes in Adults versus Type 1 Diabetes.

CONCLUSIONS: Our study highlights the usefulness of peptides as diagnostic antigens in T1DM and LADA, and extends previous findings by comparing IgM and IgG-isotype antibodies in the same population. Additionally, results highlight the role of the entourage in the shared sequon PEVKXK in GAD and CVB4P2C particularly in IgMs identification.
PMID: 33422493 [PubMed - as supplied by publisher]

Source: International Journal of Clinical Chemistry - January 7, 2021 Category: Chemistry Authors: Real-Fernández F, Gallo A, Nuti F, Altamore L, Giovanna Del Vescovo G, Traldi P, Ragazzi E, Rovero P, Lapolla A, Maria Papini A Tags: Clin Chim Acta Source Type: research