Anterior thalamic nuclei deep brain stimulation inhibits mossy fiber sprouting via 3',5'-cyclic adenosine monophosphate protein kinase A signaling pathway in a chronic epileptic monkey model.

CONCLUSION: ATN-DBS is shown to down-regulate the cAMP/PKA signaling pathway and Akt phosphorylation and to reduce the number of ectopic granule cells, which may be associated with the reduced MFS in chronic epilepsy. The study provides further insights into the mechanism by which ATN-DBS reduces epileptic seizures.
PMID: 33410631 [PubMed - as supplied by publisher]

Source: Chinese Medical Journal - January 5, 2021 Category: General Medicine Authors: Du TT, Chen YC, Zhu GY, Liu DF, Liu YY, Yuan TS, Zhang X, Zhang JG Tags: Chin Med J (Engl) Source Type: research