Antigen-specific T Cell Activation Distinguishes Between Recent and Remote Tuberculosis Infection.

CONCLUSION: The ΔHLA-DR biomarker can identify individuals with recent QuantiFERON-TB conversion and those with disease progression, allowing targeted provision of preventive treatment to those at highest risk of tuberculosis. Further validation studies of this novel immune biomarker in various settings and populations at risk are warranted.
PMID: 33406011 [PubMed - as supplied by publisher]

Source: American Journal of Respiratory and Critical Care Medicine - January 6, 2021 Category: Respiratory Medicine Authors: Mpande CAM, Musvosvi M, Rozot V, Mosito B, Reid TD, Schreuder C, Lloyd T, Bilek N, Huang H, Obermoser G, Davis MM, Ruhwald M, Hatherill M, Scriba TJ, Nemes E, ACS Study Team Tags: Am J Respir Crit Care Med Source Type: research