PPAR α/RXRα downregulates amino acid catabolism in the liver via interaction with HNF4α promoting its proteasomal degradation

The preservation of body proteins is essential to guarantee their functions in organisms. Therefore, the utilization of amino acids as energy substrates is regulated by a precise fine-tuned mechanism. Recent evidence suggests that the transcription factors peroxisome proliferator-activated receptor alpha (PPAR α) and hepatocyte nuclear factor 4 alpha (HNF4α) are involved in this regulatory mechanism. Thus, the aim of this study was to determine how these transcription factors interact to regulate the expression of amino acid catabolism genes.

Source: Metabolism - Clinical and Experimental - January 7, 2021 Category: Biomedical Science Authors: Sandra Tob ón-Cornejo, Ariana Vargas-Castillo, Alekxa Leyva-Martínez, Victor Ortíz, Lilia G. Noriega, Laura A. Velázquez-Villegas, Gabriela Aleman, Janette Furosawa, Nimbe Torres, Armando R. Tovar Source Type: research