New research finds ginger counters certain autoimmune diseases in mice
(Michigan Medicine - University of Michigan) The main bioactive compound of ginger root lowers autoantibody production and helps halt disease progression in mice with antiphospholipid syndrome and lupus.
CONCLUSION: This study shows that the thrombotic risk does not necessarily increase with the number of positive tests and raises the question of the therapeutic management of single aCL positive patients.PMID:34469630 | DOI:10.1111/jth.15518
Ann Clin Lab Sci. 2021 Jul;51(4):552-556.ABSTRACTBACKGROUND: The antiphospholipid syndrome (APS) is an autoimmune disease that is characterized by thrombosis and/or pregnancy failure and associated with the presence of all or at least one of three standard antibodies (anti-phospholipid (aPL) antibodies, including lupus anticoagulant (LA), anti-cardiolipin (aCL), and anti-β2-glycoprotein I (anti-β2GPI)). A growing body of evidence recommends adding additional aPL antibodies, such as anti-phosphatidylserine (aPS), anti-prothrombin (aPT), and anti-annexin A5 (aAA5), to conventional laboratory tests (revised Sapporo ...
We report here two cases of stroke associated with the presence of LA, and recall the strategy for screening for LA.PMID:34427558 | DOI:10.1684/abc.2021.1662
J Autoimmun. 2021 Jul 2;122:102689. doi: 10.1016/j.jaut.2021.102689. Online ahead of print.ABSTRACTElevated interleukin (IL)-21 is a common finding in the tissues and/or sera of patients with autoimmune disease. CD4 T cells are the primary producers of IL-21; often the IL-21 producing CD4 T cells will express molecules associated with follicular helper cells (TFH). Recent work has shown that the CD4 T cell-derived IL-21 is able to promote effector functions and memory differentiation of CD8 T cells in chronic infections and cancer. Autoimmunity has similarities to chronic infections and cancer. However, CD4 T cell-derived ...