Targeted Temperature Management Suppresses Hypoxia-Inducible Factor-1 α and Vascular Endothelial Growth Factor Expression in a Pig Model of Cardiac Arrest

ConclusionThe HIF-1 α/VEGF/VEGFR-2 system is activated following CA and CPR. HTTM protects against cerebral injury after ROSC, which may be part of the mechanism by which it inhibits the expression of components of the HIF-1α/VEGF/VEGFR-2 signaling pathway.

Source: Neurocritical Care - January 5, 2021 Category: Neurology Source Type: research