Treg-specific IL-2 therapy can reestablish intrahepatic immune regulation in autoimmune hepatitis.

In conclusion, complexed IL-2/anti-IL-2 restored the balance between Tregs and Teffs within the liver, thereby improving the course of emAIH. Treg-specific IL-2 augmentation offers new hope for reestablishing immune tolerance in patients with AIH.
PMID: 33387980 [PubMed - as supplied by publisher]

Source: Journal of Autoimmunity - December 30, 2020 Category: Allergy & Immunology Authors: Buitrago-Molina LE, Pietrek J, Noyan F, Schlue J, Manns MP, Wedemeyer H, Hardtke-Wolenski M, Jaeckel E Tags: J Autoimmun Source Type: research