Regulation of macrophage subsets and cytokine production in leishmaniasis.

Regulation of macrophage subsets and cytokine production in leishmaniasis. Cytokine. 2020 Dec 14;:155309 Authors: Carneiro MB, Vaz LG, Afonso LCC, Horta MF, Vieira LQ Abstract Macrophages are host cells for parasites of the genus Leishmania where they multiply inside parasitophorous vacuoles. Paradoxically, macrophages are also the cells responsible for killing or controlling parasite growth, if appropriately activated. In this review, we will cover the patterns of macrophage activation and the mechanisms used by the parasite to circumvent being killed. We will highlight the impacts of the vector bite on macrophage activation. Finally, we will discuss the ontogeny of macrophages that are infected by Leishmania spp. PMID: 33334669 [PubMed - as supplied by publisher]
Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research