Using comparative genomics to drive new discoveries in microbiology.
Using comparative genomics to drive new discoveries in microbiology. Curr Opin Microbiol. 2015 Jan 21;23C:189-196 Authors: Haft DH Abstract Bioinformatics looks to many microbiologists like a service industry. In this view, annotation starts with what is known from experiments in the lab, makes reasonable inferences of which genes match other genes in function, builds databases to make all that we know accessible, but creates nothing truly new. Experiments lead, then biocuration and computational biology follow. But the astounding success of genome sequencing is changing the annotation paradigm. Every genome sequenced is an intercepted coded message from the microbial world, and as all cryptographers know, it is easier to decode a thousand messages than a single message. Some biology is best discovered not by phenomenology, but by decoding genome content, forming hypotheses, and doing the first few rounds of validation computationally. Through such reasoning, a role and function may be assigned to a protein with no sequence similarity to any protein yet studied. Experimentation can follow after the discovery to cement and to extend the findings. Unfortunately, this approach remains so unfamiliar to most bench scientists that lab work and comparative genomics typically segregate to different teams working on unconnected projects. This review will discuss several themes in comparative genomics as a discovery method, including highly derived data, use of pa...
Publication date: Available online 25 February 2020Source: MitochondrionAuthor(s): Viraj Muthye, Dennis V. Lavrov
Publication date: Available online 24 February 2020Source: MitochondrionAuthor(s): Deepika Kundu, Ritu Pasrija
Publication date: Available online 24 February 2020Source: Microvascular ResearchAuthor(s): A. Alper Öztürk, İrem Namlı, Kadri Güleç, H. Tuba Kıyan
Publication date: Available online 25 February 2020Source: Polymer TestingAuthor(s): Cijun Shuai, Xun Yuan, Wenjing Yang, Shuping Peng, Chongxian He, Pei Feng, Fangwei Qi, Guoyong Wang
Publication date: Available online 25 February 2020Source: Polymer TestingAuthor(s): Sattaiah Naidu K, Abhijeet S. Kate, Vikas Kshirsagar, R. Ganeshan, Tukaram Gunale, Bing Zhou, Samir Anapat, Yusuf Sulub, Arun Kumar, Narayana Rao
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Zeynep Dogan, Kan’ichiro Ishiuchi, Toshiaki Makino, Iclal Saracoglu
Publication date: Available online 24 February 2020Source: Computational and Theoretical ChemistryAuthor(s): F. Paularokiadoss, A. Sekar, Thayalaraj Christopher Jeyakumar
Soft Matter, 2020, Advance Article DOI: 10.1039/C9SM02494H, PaperGhazi Ben Messaoud, Patrick Le Griel, Daniel Hermida-Merino, Niki Baccile The structure-properties relationship of lipid lamellar hydrogels composed of a biobased microbial glucolipid biosurfactant is studied against pH, temperature and shear rate usingin situ rheo-SAXS experiments. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Soft Matter, 2020, Accepted Manuscript DOI: 10.1039/D0SM00001A, Review ArticleCharles E Sing, Sarah L Perry Complex coacervation is an associative, liquid-liquid phase separation that can occur in solutions of oppositely-charged macromolecular species, such as proteins, polymers, and colloids. This process results in a coacervate phase,... The content of this RSS Feed (c) The Royal Society of Chemistry
Phys. Chem. Chem. Phys., 2020, Accepted Manuscript DOI: 10.1039/C9CP05699H, PaperMeng-Meng Wang, Yan-Xia Zhao, Xun-Lei Ding, Wei Li, Sheng-Gui He The ability of transition metals to activate methane is quite different, and it is attractive to find the most suitable metal for the direct conversion of methane to value-added chemicals.... The content of this RSS Feed (c) The Royal Society of Chemistry