Compton-camera-based SPECT for thyroid cancer imaging.

Compton-camera-based SPECT for thyroid cancer imaging. J Xray Sci Technol. 2020 Dec 05;: Authors: Yu H, Wang G Abstract Thyroid cancer is the most common type of endocrine-related cancer and the most common cancer in young women. Currently, single photon emission computed tomography (SPECT) and computed tomography (CT) are used with radioiodine scintigraphy to evaluate patients with thyroid cancer. The gamma camera for SPECT contains a mechanical collimator that greatly compromises dose efficiency and limits diagnostic sensitivity. Fortunately, the Compton camera is emerging as an ideal approach for mapping the distribution of radiopharmaceuticals inside the thyroid. In this preliminary study, based on the state-of-the-art readout chip Timepix3, we investigate the feasibility of using Compton camera for radiotracer SPECT imaging in thyroid cancer. A thyroid phantom is designed to mimic human neck, the mechanism of Compton camera-based event detection is simulated to generate realistic list-mode data, and a weighted back-projection method is developed to reconstruction the original distribution of the emission source. Study results show that the Compton camera can improve the detection efficiency for two or higher orders of magnitude comparing with the conventional gamma cameras. The thyroid gland regions can be reconstructed from the Compton camera measurements in terms of radiotracer distribution. This makes the Compton-camera-based...
Source: Journal of X-Ray Science and Technology - Category: Radiology Tags: J Xray Sci Technol Source Type: research