Vitamin D rescues pancreatic β cell dysfunction due to iron overload via elevation of the vitamin D receptor and maintenance of Ca2+ homeostasis

ConclusionsWe showed that functional failure of β cells due to iron accumulation was rescued by 1,25(OH)2D3, and iron overload significantly reduced VDR levels in β cells. These results suggest that iron and vitamin D inversely influence pancreatic β cell function.This article is protected by copyright. All rights reserved

Source: Molecular Nutrition and Food Research - December 15, 2020 Category: Food Science Authors: Yoo Jeong Lee, Gyu Hee Kim, Jin ‐soo Yoo, Sang Ick Park, Joo Hyun Lim Tags: Research Article Source Type: research