Cancers, Vol. 12, Pages 3697: Long-Term Evaluation of Women Referred to a Breast Cancer Family History Clinic (Manchester UK 1987 –2020)

Cancers, Vol. 12, Pages 3697: Long-Term Evaluation of Women Referred to a Breast Cancer Family History Clinic (Manchester UK 1987–2020) Cancers doi: 10.3390/cancers12123697 Authors: Anthony Howell Ashu Gandhi Sacha Howell Mary Wilson Anthony Maxwell Susan Astley Michelle Harvie Mary Pegington Lester Barr Andrew Baildam Elaine Harkness Penelope Hopwood Julie Wisely Andrea Wilding Rosemary Greenhalgh Jenny Affen Andrew Maurice Sally Cole Julia Wiseman Fiona Lalloo David P. French D. Gareth Evans Clinics for women concerned about their family history of breast cancer are widely established. A Family History Clinic was set-up in Manchester, UK, in 1987 in a Breast Unit serving a population of 1.8 million. In this review, we report the outcome of risk assessment, screening and prevention strategies in the clinic and propose future approaches. Between 1987–2020, 14,311 women were referred, of whom 6.4% were from known gene families, 38.2% were at high risk (≥30% lifetime risk), 37.7% at moderate risk (17–29%), and 17.7% at an average/population risk who were discharged. A total of 4168 (29.1%) women were eligible for genetic testing and 736 carried pathogenic variants, predominantly in BRCA1 and BRCA2 but also other genes (5.1% of direct referrals). All women at high or moderate risk were offered annual mammographic screening between ages 30 and 40 years old: 646 cancers were detected in wome...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research