FSHB and FSHR gene variants exert mild modulatory effect on reproductive hormone levels and testis size but not on semen quality: A study of 2,020 men from the general Danish population

ConclusionThe studied polymorphisms have only minor modulating influence on testis size and function in healthy men. We detected subtle effects of the three SNPs on FSH levels, but also effects ofFSHB‐211G>T on calculated free ‐Testosterone/LH ratio, compatible with altered Leydig cell function. Thus, the role of these FSH‐related polymorphisms is complex and modest in men with normal testicular function, but the possible importance of FSH polymorphisms in men with impaired testicular function should be evaluated in f uture studies in more detail.

Source: Andrology - November 25, 2020 Category: Urology & Nephrology Authors: Anne Kirstine Bang, Kristian Almstrup, Loa Nordkap, L ærke Priskorn, Jørgen Holm Petersen, Martin Blomberg Jensen, Marianna Krause, Stine Agergaard Holmboe, Dorte Louise Egeberg Palme, Sofia Boeg Winge, Ulla Nordström Joensen, Inge Ahlmann O Tags: ORIGINAL ARTICLE Source Type: research