Adjustments for oral fluid quality and collection methods improve prediction of circulating tetanus antitoxin: Approaches for correcting antibody concentrations detected in a non-invasive specimen.

CONCLUSIONS: Anti-TT IgG in OF is a good proxy for levels in serum, after controlling for total IgG in the specimen and other variables. Post hoc adjustments for OF volume and total IgG concentration are an important consideration when conducting serosurveys with oral fluid.
PMID: 33257104 [PubMed - as supplied by publisher]

Source: Vaccine - November 27, 2020 Category: Allergy & Immunology Authors: Garrison-Desany H, Ochieng BO, Odiere MR, Kuo H, Gibson DG, Were J, Kagucia EW, Pasetti MF, Kim H, Reymann M, O'Brien K, Hayford K Tags: Vaccine Source Type: research