Wide ‐open conformation of UDP‐MurNc‐tripeptide ligase revealed by the substrate‐free structure of MurE from Acinetobacter baumannii
In this study, we present the substrate ‐free structure of MurE fromAcinetobacter baumannii, which is an antibiotic ‐resistant superbacterium that has threatened global public health. The structure revealed that MurE has a wide‐open conformation and undergoes wide‐open, intermediately closed, and fully closed dynamic conformational transition. Unveiling structural dynamics of MurE will help to understand th e working mechanism of this ligase and to design next‐generation antibiotics targeting MurE.
Source: FEBS Letters - Category: Biochemistry Authors: Kyoung Ho Jung,
Yeon ‐Gil Kim,
Chang Min Kim,
Hyun Ji Ha,
Chang Sup Lee,
Jun Hyuck Lee,
Hyun Ho Park Tags: RESEARCH LETTER Source Type: research