Tissue-specific Immunopathology in Fatal COVID-19.

CONCLUSIONS: Tissue-specific immunopathology occurs in Covid-19, implicating a significant component of immune-mediated, virus-independent immunopathology as a primary mechanism in severe disease. Our data highlight novel immunopathological mechanisms, and validate ongoing and future efforts to therapeutically target aberrant macrophage and plasma cell responses as well as promoting pathogen tolerance in Covid-19. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). PMID: 33217246 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33217246?dopt=Abstract

Source: American Journal of Respiratory and Critical Care Medicine - November 20, 2020 Category: Respiratory Medicine Authors: Dorward DA, Russell CD, Um IH, Elshani M, Armstrong SD, Penrice-Randal R, Millar T, Lerpiniere CE, Tagliavini G, Hartley CS, Randle NP, Gachanja NN, Potey PM, Dong X, Anderson AM, Campbell VL, Duguid AJ, Al Qsous W, BouHaidar R, Baillie JK, Dhaliwal K, Wa Tags: Am J Respir Crit Care Med Source Type: research