TSHR-specific lymphocytes in Ad-TSHR-immunized native and HLA-DR3-transgenic mice and in Graves ´ disease patient blood using MHCII tetramers.

CONCLUSIONS: Novel MHC II tetramers identified TSHR-specific T lymphocytes in Ad-TSHR-immunized hyperthyroid BALB/c or HLA-DR3-transgenic mice, and in thawed human PBMCs from Graves´ patients. These assays may contribute significantly to measure both, disease severity and effects of novel immune therapies in future animal studies and clinical investigations of Graves´ disease. PMID: 33208049 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research