GSE161904 Transcriptional, behavioural and biochemical profiling in the 3xTg-AD mouse model reveals a specific signature of amyloid deposition and functional decline in Alzheimer ’s disease

Contributors : Wencheng Yin ; Navei Cerda-Hernandez ; Atahualpa Castillo-Morales ; Mayra L Ruiz-Tejada-Segura ; Jimena Monz ón-Sandoval ; Perla Moreno-Castilla ; Rodrigo Pérez-Ortega ; Federico Bermudez-Rattoni ; Araxi Urrutia ; Humberto GutierrezSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlzheimer ’s disease (AD)-related degenerative decline is associated to the presence of amyloid beta (Aβ) plaque lesions and neuro fibrillary tangles (NFT). However, the precise molecular mechanisms linking Aβ deposition and neurological decline are still unclear. Here we combine genome-wide transcription al profiling of the insular cortex of 3xTg-AD mice and control littermates from early through to late adulthood (2-14 months of age), with behavioural and biochemical profiling in the same animals to identify transcriptional determinants of functional decline specifically associated to build-up of A β deposits. Differential expression analysis revealed differentially expressed genes (DEGs) in the cortex long before observed onset of behavioural symptoms in this model. Using behavioural and biochemical data derived from the same mice and samples, we found that down but not up-regulated DEGs sh ow a stronger average association with learning performance than random background genes in control not seen in AD mice. Conversely, these same genes were found to have a stronger association with Aβ deposition than background genes in AD bu...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research