Pregnancy-related plasticity of gastric vagal afferent signals in mice.

This study aimed to determine the mechanosensitivity of GVAs and food intake during early-, mid-, and late- stages of pregnancy in mice. Pregnant mice consumed more food compared to non-pregnant mice, notably in the light phase during mid- and late pregnancy. The increased food intake was predominantly due to light phase increases in meal size across all stages of pregnancy. The sensitivity of GVA tension receptors to gastric distension was significantly attenuated in mid- and late pregnancy, while the sensitivity of GVA mucosal receptors to mucosal stroking was unchanged during pregnancy. To determine whether pregnancy associated hormonal changes drive these adaptations, the effects of estradiol, progesterone, prolactin and growth hormone, on GVA tension receptor mechanosensitivity were determined in non-pregnant female mice. The sensitivity of GVA tension receptors to gastric distension was augmented by estradiol, attenuated by growth hormone and unaffected by progesterone or prolactin. Together, the data indicate that the sensitivity of GVA tension receptors to tension is reduced during pregnancy, which may attenuate the perception of gastric fullness and explain increased food intake. Further, these adaptations may be driven by increases in maternal circulating growth hormone levels during pregnancy. PMID: 33206550 [PubMed - as supplied by publisher]
Source: Am J Physiol Gastroi... - Category: Gastroenterology Authors: Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research