Genes, Vol. 11, Pages 1367: Comprehensive Genomic Profile of Heterogeneous Long Follow-Up Triple-Negative Breast Cancer and Its Clinical Characteristics Shows DNA Repair Deficiency Has Better Prognostic
Genes, Vol. 11, Pages 1367: Comprehensive Genomic Profile of Heterogeneous Long Follow-Up Triple-Negative Breast Cancer and Its Clinical Characteristics Shows DNA Repair Deficiency Has Better Prognostic
Genes doi: 10.3390/genes11111367
Authors:
Ernesto Rojas-Jiménez
Javier César Mejía-Gómez
Clara Díaz-Velásquez
Rosalía Quezada-Urban
Héctor Martínez Gregorio
Fernando Vallejo-Lecuona
Aldo de la Cruz-Montoya
Fany Iris Porras Reyes
Víctor Manuel Pérez-Sánchez
Héctor Aquiles Maldonado-Martínez
Maybelline Robles-Estrada
Enrique Bargalló-Rocha
Paula Cabrera-Galeana
Maritza Ramos-Ramírez
Yolanda Irasema Chirino
Luis Alonso Herrera
Luis Ignacio Terrazas
Javier Oliver
Cecilia Frecha
Sandra Perdomo
Felipe Vaca-Paniagua
Triple-negative breast cancer (TNBC) presents a marked diversity at the molecular level, which promotes a clinical heterogeneity that further complicates treatment. We performed a detailed whole exome sequencing profile of 29 Mexican patients with long follow-up TNBC to identify genomic alterations associated with overall survival (OS), disease-free survival (DFS), and pathologic complete response (PCR), with the aim to define their role as molecular predictive factors of treatment response and prognosis. We detected 31 driver genes with pathogenic mutations in TP53 (53%), BRCA1/2 (27%), CDKN1B (9%), PIK3CA (9%), and PTEN (9%), and 16 operative mutational signatures. Moreover, tumors with mutations in BRCA1/2...
Source: Genes - Category: Genetics & Stem Cells Authors: Ernesto Rojas-Jim énez Javier C ésar Mejía-Gómez Clara D íaz-Velásquez Rosal ía Quezada-Urban H éctor Martínez Gregorio Fernando Vallejo-Lecuona Aldo de la Cruz-Montoya Fany Iris Porras Reyes V íctor Manuel Pérez-Sánchez H éctor Aquiles Maldo Tags: Article Source Type: research
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