Discriminating Multisystem Inflammatory Syndrome in Children Requiring Treatment from Common Febrile Conditions in Outpatient Settings

To examine whether patients with multisystem inflammatory syndrome in children (MIS-C) demonstrated well-defined clinical features distinct from other febrile outpatients, given the difficulties of seeing acute care visits during the severe acute respiratory syndrome coronavirus 2 pandemic and the risks associated with both over- and underdiagnosis of MIS-C.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Original Articles Source Type: research

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In this study, we consider an alternative design where we recruit among all individuals, symptomatic and asymptomatic, being tested for the virus in addition to population controls. We define a regression parameter related to a prospective risk factor analysis and investigate its identifiability under the two study designs. We review the difference between the prospective risk factor parameter and the parameter targeted in the typical TND where only symptomatic and tested people are recruited. Using missing data directed acyclic graphs, we provide conditions and required data collection under which identifiability of the p...
Source: Epidemiology - Category: Epidemiology Tags: Infectious Diseases Source Type: research
Getting the kids ready to go back to school each fall is stressful enough in a normal year, never mind in the midst of a pandemic. Between the more transmissible Delta coronavirus variant, rising cases across the country and new masking guidance from the U.S. Centers for Disease Control and Prevention (CDC), there’s a lot for parents to navigate as they plan for schools to reopen this August and September. On the whole, experts seem to agree it’s time to get kids back into their classrooms. Remote learning set many children—especially students of color—back academically, cut them off from essential ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
This article summarizes the possible therapeutic potential and benefits of using montelukast, a cysteinyl leukotriene 1 (CysLT1) receptor antagonist, to control COVID-19 pathophysiology. Montelukast has shown anti-inflammatory effects, reduced cytokine production, improvement in post-infection cough production and other lung complications.Key Messages: Recent reports clearly indicate a distinct role of CysLT-regulated cytokines and immunological signaling in COVID-19. Thus, montelukast may have a clinical potential to control lung pathology during COVID-19.Pharmacology
Source: Pharmacology - Category: Drugs & Pharmacology Source Type: research
ABSTRACTThe COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, has triggered a worldwide health emergency. Here, we show that ferritin-like Dps from hyperthermophilicSulfolobus islandicus, covalently coupled with SARS-CoV-2 antigens via the SpyCatcher system, forms stable multivalent dodecameric vaccine nanoparticles that remain intact even after lyophilisation. Immunisation experiments in mice demonstrated that the SARS-CoV-2 receptor binding domain (RBD) coupled to Dps (RBD-S-Dps) elicited a higher antibody titre and an enhanced neutralising antibody response compared to monomeric RBD. A single immunisation with RB...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: RESEARCH LETTER Source Type: research
Conclusion: The AN procedure, which was used within 72 h after the admission of patients with COVID-19, was safe and could be successfully implemented during the first two waves of COVID-19 in France. Nevertheless, AN did not significantly improve the outcome of the patients in our small preliminary study. It is pertinent to explore further to validate AN as the non-invasive mass vagal stimulation solution for the forthcoming pandemics.Clinical Trial Registration: [https://clinicaltrials.gov/], identifier [NCT04341415].
Source: Frontiers in Physiology - Category: Physiology Source Type: research
The current worldwide pandemic of the 2019 coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) poses a significant threat to global health and economy. The clinical presentation varies widely among individuals from mild afebrile respiratory symptoms to severe illness causing acute respiratory distress syndrome (ARDS).1 Approximately 5% of infected persons require admission to an intensive care unit and approximately 12% of hospitalized COVID-19 persons receive mechanical ventilation.
Source: Heart and Lung - Category: Intensive Care Authors: Source Type: research
Semin Hear 2021; 42: 088-097 DOI: 10.1055/s-0041-1731689Providing same-day hearing aid fitting appointments to patients being seen in an audiology clinic for an audiometric evaluation may help decrease clinic wait times and reduce the need for future in-person appointments. Prior to 2020, the Veterans Administration (VA) Healthcare System did not allow hearing aid manufacturers to provide functional demonstration (demo) hearing aids to VA audiology clinics. Due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19) pandemic, this rule was changed to minimize the number of required in-person VA audiolo...
Source: Seminars in Hearing - Category: Audiology Authors: Tags: Review Article Source Type: research
AbstractCoronavirus disease 2019 (COVID-19) is an infectious disease caused by a new species of β-coronavirus genus named severe acute respiratory syndrome coronavirus 2. The COVID-19 pandemic, which started in late 2019 and continues as at mid-2021, has caused enormous damage to health and lives globally. The urgent public health need has led to the development of vaccines against COVID-19 i n record-breaking time. The COVID-19 vaccines have been widely rolled out for the masses by many countries following approval for emergency use by the World Health Organization and regulatory agencies in many countries. In additi...
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
In December, 2019, the coronavirus 2019 disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in Wuhan, China [1]. COVID-19 disseminated rapidly throughout China and subsequently to the rest of the world resulting in a declaration of the disease as a pandemic by the World Health Organization on March 11, 2020 [2]. This disease produced a wide clinical spectrum in infected patients ranging from asymptomatic carriers to critical illness and fatalities.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Original articles Source Type: research
Objective: The coronavirus disease 2019 (COVID-19) infection may alter a stroke course; thus, we compared stroke course during subsequent pandemic waves in a stroke unit (SU) from a hospital located in a rural area.Methods: A retrospective study included all patients consecutively admitted to the SU between March 15 and May 31, 2020 (“first wave”), and between September 15 and November 30, 2020 (“second wave”). We compared demographic and clinical data, treatments, and outcomes of patients between the first and the second waves of the pandemic and between subjects with and without COVID-19.Results: ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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