Prognostic significance of CD133 and ABCB5 expression in papillary thyroid carcinoma

Expression of CD133 and ABCB5 is associated with tumor aggressiveness, but evidence in papillary thyroid cancer (PTC) is lacking. We correlated CD133 and ABCB5 expression with pathological characteristics and factors of worse prognosis in PTC. Samples of 119 PTCs and 40 controls (goiters) were distributed in 8 tissue microarray blocks and evaluated with immunohistochemistry using anti-CD133 and anti-ABCB5 antibodies. The expression of each marker alone and combined was analyzed against pathological characteristics and factors of worse prognosis in PTC. Expression of CD133 alone (19 tumors, 16.0%) was more frequent in patients withversus without lymph node metastases (P=0.024). Expression of ABCB5 alone (n=95, 83.3%) was associated with larger tumor size (P=0.045). CD133-ABCB5 coexpression was not associated with pathological characteristics or factors of worse prognosis in PTC.

Source: European Journal of Histochemistry - November 12, 2020 Category: Biomedical Science Authors: Maria Augusta Karas Zella, Ana Paula Martins Sebasti ão, Luiz Martins Collaço, Daniel Cury Ogata, Guilherme Cecchetti, Ivan José Paredes Bartolomei, Ana Maria Waaga-Gasser, Carmen Australia Paredes Marcondes Ribas Source Type: research