Onset of action of inhaled glucocorticoids on bronchial and alveolar nitric oxide output

Fractional exhaled nitric oxide (F E NO) is a marker of airway inflammation. Measuring F E NO at multiple flow rates enables calculation of NO parameters: bronchial NO output ( J aw NO), bronchial wall ( C aw NO) and alveolar ( C A NO) NO concentrations, and bronchial diffusion factor of NO ( D aw NO). F E NO is known to rapidly reduce after the commencement of inhaled corticosteroid (ICS) treatment. However, little is known on the effect of ICS on the other NO parameters. We assessed (1) the onset of action of ICS treatment on the NO parameters and (2) whether the changes in bronchial NO output are due to changes in bronchial wall NO concentration or diffusion factor. F E NO and other NO parameters were measured at baseline and after 1, 3 and 7 d of treatment with inhaled fluticasone propionate 250 μ g b.i.d. in 23 allergic children with a history of asthma-like symptoms. T...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Source Type: research