Onset of action of inhaled glucocorticoids on bronchial and alveolar nitric oxide output
Fractional exhaled nitric oxide (F E NO) is a marker of airway inflammation. Measuring F E NO at
multiple flow rates enables calculation of NO parameters: bronchial NO output ( J aw NO), bronchial
wall ( C aw NO) and alveolar ( C A NO) NO concentrations, and bronchial diffusion factor of NO ( D
aw NO). F E NO is known to rapidly reduce after the commencement of inhaled corticosteroid (ICS)
treatment. However, little is known on the effect of ICS on the other NO parameters. We assessed (1)
the onset of action of ICS treatment on the NO parameters and (2) whether the changes in bronchial
NO output are due to changes in bronchial wall NO concentration or diffusion factor. F E NO and
other NO parameters were measured at baseline and after 1, 3 and 7 d of treatment with inhaled
fluticasone propionate 250 μ g b.i.d. in 23 allergic children with a history of asthma-like
symptoms. T...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Tuomas Karvonen, Anna Sepponen-Lavikko, Kati Holm, R üdiger Schultz, Eeva Moilanen and Lauri Lehtimäki Source Type: research
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