Association of plasma docetaxel levels with ABCB1 gene polymorphisms and tumour response in locally advanced breast cancer patients of South India on neo-adjuvant chemotherapy.

CONCLUSIONS: The plasma levels of docetaxel were significantly influenced by the SNP C1236T of ABCB1 gene coding for the MDR1 transporter (P-glycoprotein). The plasma levels of docetaxel were also found to influence its therapeutic effect. PMID: 33125673 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33125673?dopt=Abstract

Source: Breast Cancer - October 30, 2020 Category: Cancer & Oncology Authors: Priyadarshini R, Raj GM, Sundaram R, Kayal S, Ramesh A, Shewade DG Tags: Breast Cancer Source Type: research