Drug concentration estimation using contrast-enhanced MRI in intra-arterial chemotherapy for head and neck cancers
In cases of head and neck cancer treated with intra-arterial chemotherapy, no objective indices are available for determining the distribution of anticancer drugs administered to multiple arteries. To establish such indices, noninvasive measurements of drug concentrations are required in the arterial perfusion area of each artery. In MRI, changes in 1/T1 ( Δ1/T1) are correlated with the contrast agent concentration. We focused on these properties and investigated whether it is possible to estimate anticancer drug concentrations within tissue based on Δ1/T1.
Source: Auris, Nasus, Larynx - Category: ENT & OMF Authors: Shintaro Ito, Nobukazu Fuwa, Miwako Nomura, Suguru Ota, Takayuki Morishima, Takashi Daimon, Yoshikazu Maeda, Jun Ueda, Iwai Tohnai, Noriko Ii, Tosiaki Miyati Tags: Original Article Source Type: research
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