Breath markers for therapeutic radiation
This study evaluated changes in exhaled breath volatile
organic compounds (VOC) associated with radiotherapy with thermal desorption gas chromatography
mass-spectrometry followed by data processing and multivariate statistical analysis. Further the
feasibility of adopting gas chromatography ion mobility spectrometry for radiotherapy point-of-care
breath was assessed. A total of 62 participants provided 240 end-tidal 1 dm 3 breath samples before
radiotherapy and at 1, 3, and 6 h post-exposure, that were analysed by
thermal-desorption/gas-chromatography/quadrupole mass-spectrometry. Data were registered by
retention-index and mass-spectra before multivariate statistical analyses identified candidate
markers. A panel of sulfur con...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Dahlia Salman, Michael Eddleston, Kareen Darnley, William H Nailon, Duncan B McLaren, Andria Hadjithelki, Dorota Ruszkiewicz, Jens Langejuergen, Yaser Alkhalifa, Iain Phillips and C L Paul Thomas Source Type: research